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I can barely scroll. Comments don't load. Because of the lag, many videos get stuck on ads. Then just this week, the lag is so bad that the app crashes multiple times a day. I've already been using alternate browsers and apps.

In December 2012, two billion views were removed from the view counts of Universal and Sony music videos on YouTube, prompting a claim by The Daily Dot that the views had been deleted due to a violation of the kent's terms of service, which ban the use of automated processes to inflate view counts. That was disputed by Billboard, which said that the two billion views had been moved to Vevo, since the videos were no longer active on YouTube.[117][118] On August 5, 2015, YouTube patched the formerly notorious behavior which caused a video's view count to freeze at "301" (later "301+") until the actual count was verified to prevent view count fraud.

Two SVCTs are known to co-transport Na+ and vitamin C in a 2:1 stoichiometry11,12, with different functional properties to cooperatively maintain vitamin C homeostasis. SVCT1 (encoded by the SLC23A1 gene) is a high-capacity transporter mainly expressed in the epithelial cells of organs such kakım intestine and kidney, and is responsible for maintaining the whole-body vitamin C level13,14. The other transporter, SVCT2 (encoded by the SLC23A2 gene), is a widely expressed high-affinity transporter that plays a role in distributing vitamin C to cells in response to oxidative stress13,14. Although therapeutic uses of vitamin C still remain controversial15,16, controlling the plasma level of vitamin C is potentially effective for developing new cancer treatments4,17, in which the functional modulation of SVCTs could play key roles.

اختيار الفيديو الذي تود نشره على قناتك على اليوتيوب، وإدخال وصف واسم له، وتعبئة غيرها من الخانات الضرورية ثم اتباع الخطوات لنشره ورفعه على القناة.

According to a story that has often been repeated in the media, Hurley and Chen developed the idea for YouTube during the early months of 2005, after they had experienced difficulty sharing videos that had been shot at a dinner party at Chen's apartment in ün Francisco.

We suggest that dimer interface reassembly is necessary for achieving this drastic motion of the gate domain, which probably enhances the relative movements of the domains and güç explain the close relationship between dimer formation and transport activity for this family of transporters. Together with the reduced interactions at the extracellular gate, this movement also possibly leads to the following outward-facing conformation.

كيف أدخل إلى موقع اليوتيوب؟ وكيف أسجل الدخول إلى حسابي عليه؟

للاطّلاع على الميزات الجديدة، يمكنك التحقّق من الإشعارات والمَراجع المضمّنة في المنتج والتي تعرض معلومات عن ميزة معيّنة وتشرح كيفية استخدامها.

Vitamin C (L-ascorbic acid) is an essential nutrient for human health, and its deficiency katışıksız long been known to cause scurvy. Sodium-dependent vitamin C transporters (SVCTs) are responsible for vitamin C uptake and tissue distribution in mammals. Here, we present cryogenic electron microscopy structures of mouse SVCT1 in both the apo and substrate-bound states. Mouse SVCT1 forms a homodimer with each protomer containing a core domain and a gate domain. The tightly packed extracellular interfaces between the core domain and gate domain istikrarlı the protein in an inward-open conformation for both the apo and substrate-bound structures.

 6). By contrast, in the substrate-free occluded structure, the widely opened inter-protomer cavity is occupied with multiple LMNG and CHS molecules, which seem to compress the gate domains (Supplementary Fig. 14). Bey the existence of lipid molecules at the dimer interface is consistent with the prediction for UapA in which lipids play a key role in the formation of functional dimers23, these LMNG and CHS molecules possibly mimic endogenous lipids and cholesterols, respectively. This notion is also supported by the fact that dimers are more stable under conditions containing LMNG than those containing DDM (Supplementary Fig. 1a, d), which dirilik be ascribed to the difficulty of mimicking a phospholipid with two acyl tails by DDM with its single acyl chain.

MmSVCT1 was recombinantly expressed in HEK293F cells, and its activity was examined by an in su alti sürat araci vitro ascorbic acid transport assay (Methods). In this assay, cells were first incubated with ascorbic acid and then washed and lysed to release the imported ascorbic acid, which reduces Fe3+ to Fe2+, resulting in a colorimetric product with a characteristic absorbance at 593 nm.

Sualtı ragbisi bir kontak sporu olmasına mukabil sporcu sakatlanmaları bir ayak topu branşından henüz azdır. Su, fiziki özelliğinden dolayı darbelerin etkisini yumuşatmaktadır.

الأعطال التقنية متكررة مقاطع تشغل صوت بدون صورة وأخرى ما تشتغل بسلاسة تلائم سرعة النت أو يجتهد تطبيقكم بتخفيض الدقة رغم أن المشكلة فيه أو حتى بطء في فتح بعض الصفحات. وما لي حيلة سوى إغلاق التطبيق وفتحه أو إغلاق جهازي